Reloading PyXLL won't cause Excel to recalculate automatically.
The easiest way to recalculate everything after reloading is to use the Excel shortcut Ctrl+Alt+F9.
If you want to always recalculate automatically when reloading PyXLL you can use an @xl_on_reload callback to do that.
In your @xl_on_reload callback, you can use the Excel method "Application.CalculateFull", for example:
In the example code above I have used PyXLL's "schedule_call" function to schedule the call to recalculate Excel. This ensures that reloading has finished before recalculating, as well as making sure that the xl_app function is being used safely (it should only be called from certain places, including macros and functions called using schedule_call).
Microsoft has a good page on how Excel recalculation works if you need more information about how recalculation works in Excel
https://learn.microsoft.com/en-us/office/client-developer/excel/excel-recalculation.